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bupleurum falcatum root extract
extract of the roots of bupleurum falcatum l., apiaceae

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CAS Number:	89958-12-3
ECHA EC Number:	289-634-9
FDA UNII:	Search

Category:cosmetic ingredient for skin conditioning

US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:

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Physical Properties:

Food Chemicals Codex Listed:

No

Organoleptic Properties:

Odor and/or flavor descriptions from others (if found).

Cosmetic Information:

CosIng:	cosmetic data
Cosmetic Uses:	skin conditioning

Suppliers:

Changsha Organic Herb

Bupleurum Falcatum Extract

Qingdao Dacon Trading

Bupleurum Falcatum Extract

Safety Information:


Hazards identification

Classification of the substance or mixture
GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)
None found.
GHS Label elements, including precautionary statements

Pictogram

Hazard statement(s)
None found.
Precautionary statement(s)
None found.
Oral/Parenteral Toxicity:
oral-mouse LD50 4700 mg/kg BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 712, 1969. intravenous-mouse LD50 70 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 712, 1969. intraperitoneal-mouse LD50 112 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 712, 1969. intraperitoneal-guinea pig LD50 58 mg/kg BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 712, 1969.
Dermal Toxicity:
subcutaneous-mouse LD50 175 mg/kg BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Yakugaku Zasshi. Journal of Pharmacy. Vol. 89, Pg. 712, 1969.
Inhalation Toxicity:
Not determined

Safety in Use Information:

Category:
cosmetic ingredient for skin conditioning
Recommendation for bupleurum falcatum root extract usage levels up to:
	not for fragrance use.

Recommendation for bupleurum falcatum root extract flavor usage levels up to:
	not for flavor use.

Safety References:

AIDS Citations:Search

Cancer Citations:Search

Toxicology Citations:Search

EPA ACToR:Toxicology Data

EPA Substance Registry Services (SRS):Registry

National Institute of Allergy and Infectious Diseases:Data

bupleurum falcatum root extract

Chemidplus:008 000 000-00-00

References:

	bupleurum falcatum root extract
Pubchem (sid):	135349087

Other Information:

Wikipedia:

Potential Blenders and core components note

None Found

Potential Uses:

None Found

Occurrence (nature, food, other):note

bupleurum falcatum root
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Synonyms:

	bupleurum rossicum root extract
	chinese thoroughwax root extract
	extract of the roots of bupleurum falcatum l., apiaceae
	sickle hare's ear root extract
	sickle hares ear root extract
	sickle-leaf hare's ear root extract
	sickle-leaf hares ear root extract

Articles:

PubMed:Separation of triterpenoid saponins from the root of Bupleurum falcatum by countercurrent chromatography: The relationship between the partition coefficients and solvent system composition.

PubMed:Cell type-specific qualitative and quantitative analysis of saikosaponins in three Bupleurum species using laser microdissection and liquid chromatography-quadrupole/time of flight-mass spectrometry.

PubMed:Large-scale production of saikosaponins through root culturing of Bupleurum falcatum L. using modified airlift reactors.

PubMed:Gene regulation patterns in triterpene biosynthetic pathway driven by overexpression of squalene synthase and methyl jasmonate elicitation in Bupleurum falcatum.

PubMed:Comparison between evaporative light scattering detection and charged aerosol detection for the analysis of saikosaponins.

PubMed:Optimization of supercritical fluid extraction of saikosaponins from Bupleurum falcatum with orthogonal array design.

PubMed:[Determination of the contents of trace elements in chinese herbal medicines for treating respiratory system diseases].

PubMed:Upregulation of isoprenoid pathway genes during enhanced saikosaponin biosynthesis in the hairy roots of Bupleurum falcatum.

PubMed:Toxicological aspects of Kampo medicines in clinical use.

PubMed:Efficient production of saikosaponins in Bupleurum falcatum root fragments combined with signal transducers.

PubMed:Effects of a pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. on interleukin 6 production of murine B cells and B cell lines.

PubMed:B-cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. and its structural requirement.

PubMed:Characterization of antigenic epitopes in anti-ulcer pectic polysaccharides from Bupleurum falcatum L. using several carbohydrases.

PubMed:Saponins from the root of Bupleurum falcatum.

PubMed:[Production of medicinal plants by soilless culture system. I. Studies of morphological characteristics and saikosaponins content in Bupleurum falcatum cultivated by Ebb & Flood system].

PubMed:Amplification and sequence of a 5s-rRNA gene spacer region from the crude drug "angelica root".

PubMed:Characterisation of the endo-polygalacturonase-resistant region of the pectin from Bupleurum falcatum L.--a polysaccharide with an active function in clearance of immune complexes.

PubMed:[High yield techniques for bupleurum falcatum L].

PubMed:Characterization of the immunoregulatory action of saikosaponin-d.

PubMed:Structural studies of endopolygalacturonase-resistant fragments of an antiulcer pectin from the roots of Bupleurum falcatum L.

PubMed:Purification of anti-ulcer polysaccharides from the roots of Bupleurum falcatum.

PubMed:Partial structure of an anti-ulcer pectic polysaccharide from the roots of Bupleurum falcatum L.

PubMed:Corticosterone secretion-inducing activity of saikosaponin metabolites formed in the alimentary tract.

PubMed:Characteristics of Bupleurum falcatum plants propagated through somatic embryogenesis of callus cultures.

PubMed:Structure and action of saikosaponins isolated from Bupleurum falcatum L. II. Metabolic actions of saikosaponins, especially a plasma cholesterol-lowering action.

PubMed:Structure and actions of saikosaponins isolated from Bupleurum falcatum L. I. Anti-inflammatory action of saikosaponins.

PubMed:[Notes on the dry root-rot disease of Bupleurum falcatum L. VI. Soil fungicide test. (2)].

PubMed:[ON DRY ROOT-ROT DISEASE OF BUPLEURUM FALCATUM L. (2) PATHOGENESIS OF ISOLATED FUNGI].

PubMed:[ON DRY ROOT-ROT DISEASE OF BUPLEURUM FALCATUM L. (1) ISOLATION OF PATHOGENESIS FUNGI FROM THE LEAF, STEM AND ROOT].

Notes:

None found

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