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Category:antimicrobial agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 77.00 to 83.00 °C. @ 760.00 mm Hg
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| Flash Point: | 32.00 °F. TCC ( 0.00 °C. ) (est)
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| logP (o/w): | 1.710 |
| Soluble in: |
| | water | | | chloroform | | | water, 246.6 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor Description:at 100.00 %. pyridine |
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 200 mg/kg
Yakkyoku. Pharmacy. Vol. 31, Pg. 471, 1980.
intraperitoneal-rat LD50 6 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 35, Pg. 89, 1946.
oral-rabbit LD50 400 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 208, 1966.
intravenous-rabbit LD50 36 mg/kg
Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. Vol. -, Pg. 208, 1966.
oral-mouse LD50 108 mg/kg
Proceedings of the Society for Experimental Biology and Medicine. Vol. 120, Pg. 511, 1965.
intravenous-mouse LD50 10 mg/kg
Journal of Biological Standardization. Vol. 1, Pg. 87, 1973.
intraperitoneal-mouse LD50 7 mg/kg
Journal of Pharmaceutical Sciences. Vol. 59, Pg. 188, 1970.
oral-cat LD > 500 mg/kg
Journal of Pharmaceutical Sciences. Vol. 59, Pg. 188, 1970.
oral-dog LD > 500 mg/kg
Journal of Pharmaceutical Sciences. Vol. 59, Pg. 188, 1970.
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| Dermal Toxicity: |
subcutaneous-rat LD50 250 mg/kg
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 35, Pg. 89, 1946.
skin-rabbit LDLo 2000 mg/kg
Journal of Pharmaceutical Sciences. Vol. 59, Pg. 188, 1970.
subcutaneous-rabbit LD50 300 mg/kg
Drugs in Japan Vol. -, Pg. 544, 1990.
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| Inhalation Toxicity: |
inhalation-rat LC50 90mg/m3/4H Food and Chemical Toxicology. Vol. 29, Pg. 851, 1991.
inhalation-rat LC50 90 mg/m3/4H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE
Food and Chemical Toxicology. Vol. 29, Pg. 851, 1991.
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Safety in Use Information:
| Category: | | antimicrobial agents |
| Recommendation for cetyl pyridinium chloride anhydrous usage levels up to: | | | not for fragrance use.
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| Recommendation for cetyl pyridinium chloride anhydrous flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
| (IUPAC): | Atomic Weights of the Elements 2011 (pdf) |
| Videos: | The Periodic Table of Videos |
| tgsc: | Atomic Weights use for this web site |
| (IUPAC): | Periodic Table of the Elements |
| CHEBI: | View |
| CHEMBL: | View |
| HMDB (The Human Metabolome Database): | Search |
| FDA Listing of Food Additive Status: | View |
| ChemSpider: | View |
| Wikipedia: | View |
Formulations/Preparations:
•cepacaine soln (benzocaine, combination, cetylpyridinium chloride, dibucaine).
•cetylpridinium chloride lozenges, 0.067% with benzyl alc (cepacol). lozenges, 0.067% with neomycin sulfate 2.5 mg tyrothricin 1 mg, methylparaben 4 mg, propylparaben 1 mg, ethyl aminobenzoate 5 mg (cepacol antibiotic troches). soln, 0.025% with alc 14% & phosphate buffers; 150 & 420 ml bottles (cepacol).
•available as aqueous or alcohol solutions (eg, tincture) in concn of 10% or less.
•grades: technical; nf
•lozenges, 0.07%. mouthwash, 0.05%.
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Potential Blenders and core components note
Potential Uses:
| | antimicrobial agents |
| | antistatic agents |
| | deodorants |
| | emulsifying agents |
| | surfactants |
Occurrence (nature, food, other): note
Synonyms:
| | acetoquat CPC | | | cecure | | | ceepryn chloride | | | cepacol chloride | | | ceprim | | | cetafilm | | | cetamium | | 1- | cetylpyridinium chloride | | N- | cetylpyridinium chloride | | | cetylpyridinium chloride anhydrous | | | cetylpyridinium chloride USP | | | cetylpyridiniumchloride | | | CPC | | | dobendan | | | halest | | | hexadecyl pyridinium chloride anhydrous | | 1- | hexadecylpyridin-1-ium chloride anhydrous | | | hexadecylpyridinium chloride | | 1- | hexadecylpyridinium chloride | | N- | hexadecylpyridinium chloride | | | ipanol | | | medilave | | | mercocet | | | merothol | | 1- | palmitylpyridinium chloride | | | pionin B | | | pristacin | | | pyridinium, 1-hexadecyl-, chloride | | | pyridinium, 1-hexadecyl-, chloride (1:1) | | | pyridinium, hexadecyl-, chloride | | | pyrisept | | | tserigel |
Articles:
| PubMed:Selective removal and inactivation of bacteria by nanoparticle composites prepared by surface modification of montmorillonite with quaternary ammonium compounds. |
| PubMed:Development of antimicrobial resistance in Campylobacter jejuni and Campylobacter coli adapted to biocides. |
| PubMed:Effects of efflux-pump inducers and genetic variation of the multidrug transporter cmeB in biocide resistance of Campylobacter jejuni and Campylobacter coli. |
| PubMed:Involvement of efflux mechanisms in biocide resistance of Campylobacter jejuni and Campylobacter coli. |
| PubMed:Microbiological quality of water immersion-chilled and air-chilled broilers. |
| PubMed:Survival of Escherichia coli O157:H7 in meat product brines containing antimicrobials. |
| PubMed:Thin-layer chromatographic plates with monolithic layer of silica: Production, physical-chemical characteristics, separation capabilities. |
| PubMed:Physiological and transcriptional characterization of persistent and nonpersistent Listeria monocytogenes isolates. |
| PubMed:A novel method for quantitative determination of tea polysaccharide by resonance light scattering. |
| PubMed:Thermal inactivation of acid, cold, heat, starvation, and desiccation stress-adapted Escherichia coli O157:H7 in moisture-enhanced nonintact beef. |
| PubMed:Evaluation of brining ingredients and antimicrobials for effects on thermal destruction of Escherichia coli O157:H7 in a meat model system. |
| PubMed:Effect of Hofmeister anions on micellization and micellar growth of the surfactant cetylpyridinium chloride. |
| PubMed:Chemical decontamination of Campylobacter jejuni on chicken skin and meat. |
| PubMed:Linear-to-branched micelles transition: a rheometry and diffusing wave spectroscopy (DWS) study. |
| PubMed:Ultrasound velocimetry in a shear-thickening wormlike micellar solution: evidence for the coexistence of radial and vorticity shear bands. |
| PubMed:[Sorption characteristics of surfactant onto bentonite using microwave irradiation]. |
| PubMed:A significant role for Sigma B in the detergent stress response of Listeria monocytogenes. |
| PubMed:Food as a vehicle for transmission of Shiga toxin-producing Escherichia coli. |
| PubMed:Multistate outbreak of Burkholderia cenocepacia colonization and infection associated with the use of intrinsically contaminated alcohol-free mouthwash. |
| PubMed:Anticalculus effect of a cetylpyridinium chloride/zinc gluconate mucoadhesive gel: results of a randomized, double-blind, controlled clinical trial. |
| PubMed:Spectrophotometric study of anionic azo-dye light yellow (X6G) interaction with surfactants and its micellar solubilization in cationic surfactant micelles. |
| PubMed:Inhibition of Escherichia coli O157:H7, Listeria monocytogenes and Staphylococcus aureus on sliced roast beef by cetylpyridinium chloride and acidified sodium chlorite. |
| PubMed:Effects of acidified sodium chlorite, cetylpyridinium chloride and hot water on populations of Listeria monocytogenes and Staphylococcus aureus on beef. |
| PubMed:Differential killing activity of cetylpyridinium chloride with or without bacto neutralizing buffer quench against firmly adhered Salmonella gaminara and Shigella sonnei on cut lettuce stored at 4 degrees C. |
| PubMed:Fast determination of anions on a short coated column. |
| PubMed:Efficacy of cetylpyridinium chloride against Listeria monocytogenes and its influence on color and texture of cooked roast beef. |
| PubMed:3D-QSAR, synthesis, and antimicrobial activity of 1-alkylpyridinium compounds as potential agents to improve food safety. |
| PubMed:Antimicrobial activity of cetylpyridinium chloride against Listeria monocytogenes on frankfurters and subsequent effect on quality attributest. |
| PubMed:Cetylpyridinium chloride treatment of ready-to-eat Polish sausages: effects on Listeria monocytogenes populations and quality attributes. |
| PubMed:Effect of simulated spray chilling with chemical solutions on acid-habituated and non-acid-habituated Escherichia coli O157:H7 cells attached to beef carcass tissue. |
| PubMed:Effect of chemical decontamination and refrigerated storage on the isolation of Mycobacterium avium subsp. paratuberculosis from heat-treated milk. |
| PubMed:Prevalence of Escherichia coli O157 and levels of aerobic bacteria and Enterobacteriaceae are reduced when hides are washed and treated with cetylpyridinium chloride at a commercial beef processing plant. |
| PubMed:Sensitivity of Escherichia coli O157:H7 to commercially available alkaline cleaners and subsequent resistance to heat and sanitizers. |
| PubMed:Effects of cetylpyridinium chloride, acidified sodium chlorite, and potassium sorbate on populations of Escherichia coli O157:H7, Listeria monocytogenes, and Staphylococcus aureus on fresh beef. |
| PubMed:Protocol for evaluating the efficacy of cetylpyridinium chloride as a beef hide intervention. |
| PubMed:Comparative evaluation of the MGIT and BACTEC culture systems for the recovery of Mycobacterium avium subsp. paratuberculosis from milk. |
| PubMed:Reduction of poliovirus 1, bacteriophages, Salmonella montevideo, and Escherichia coli O157:H7 on strawberries by physical and disinfectant washes. |
| PubMed:Incidence of Mycobacterium paratuberculosis in bulk raw and commercially pasteurized cows' milk from approved dairy processing establishments in the United Kingdom. |
| PubMed:Survival of Listeria monocytogenes in commercial food-processing equipment cleaning solutions and subsequent sensitivity to sanitizers and heat. |
| PubMed:Effect of commercial-scale high-temperature, short-time pasteurization on the viability of Mycobacterium paratuberculosis in naturally infected cows' milk. |
| PubMed:Efficacy of cetylpyridinium chloride in immersion treatment for reducing populations of pathogenic bacteria on fresh-cut vegetables. |
| PubMed:Antimicrobial activity of cetylpyridinium chloride washes against pathogenic bacteria on beef surfaces. |
| PubMed:The effects of antimicrobial mouthrinses on oral malodor and their status relative to US Food and Drug Administration regulations. |
| PubMed:Recovery of thuringiensin with cetylpyridinium chloride using micellar-enhanced ultrafiltration process |
| PubMed:Spraying chicken skin with selected chemicals to reduce attached Salmonella typhimurium. |
| PubMed:Use of antimicrobial spray applied with an inside-outside birdwasher to reduce bacterial contamination on prechilled chicken carcasses. |
| PubMed:Cetylpyridinium chloride (CPC) treatment on poultry skin to reduce attached Salmonella. |
| PubMed:Ocular and dermal irritation studies of some quaternary ammonium compounds. |
| PubMed:Dietary staining in vitro by mouthrinses as a comparative measure of antiseptic activity and predictor of staining in vivo. |
| PubMed:Acute inhalation toxicity of cetylpyridinium chloride. |
| PubMed:Binding of dyes to hydroxyapatite treated with cetylpyridinium chloride or cetrimonium bromide. |
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3D/inchi