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Category:antioxidants
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | white powder (est) |
| Assay: | 98.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 68.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 334.00 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 0.000092 mmHg @ 25.00 °C. (est) |
| Flash Point: | 311.00 °F. TCC ( 155.20 °C. ) (est)
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| logP (o/w): | 3.450 |
| Soluble in: |
| | acetone | | | ether | | | water, 500 mg/L @ 18C (exp) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 550 mg/kg
Journal of Pharmacology and Experimental Therapeutics. Vol. 53, Pg. 198, 1935.
oral-mouse LD50 1040 mg/kg
Pharmazie. Vol. 30, Pg. 147, 1975.
intraperitoneal-mouse LD50 335 mg/kg
Japanese Kokai Tokyo Koho Patents. Vol. #90-292213
oral-guinea pig LDLo 400 mg/kg
Proceedings of the Society for Experimental Biology and Medicine. Vol. 28, Pg. 609, 1931.
unreported-mouse LDLo 100 mg/kg
Annals of Tropical Medicine and Parasitology. Vol. 32, Pg. 177, 1938.
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| Dermal Toxicity: |
subcutaneous-mouse LDLo 750 mg/kg
"Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59Vol. 5, Pg. 148, 1959.
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | antioxidants |
| Recommendation for 4-hexyl resorcinol usage levels up to: | | | not for fragrance use.
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| Recommendation for 4-hexyl resorcinol flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | benzenediol, 4-hexyl- | | 1,3- | benzenediol, 4-hexyl- | | | caprokol | | 1,3- | dihydroxy-4-hexyl benzene | | | gelovermin | | | hexyl resorcinol | | 4- | hexyl-1,3-benzenediol | | 4- | hexyl-1,3-dihydroxybenzene | | 4- | hexyl-benzene-1,3-diol | | 4- | hexylbenzene-1,3-diol | | 4- | hexylbenzol-1,3-diol | | | hexylresorcin | | 4- | hexylresorcine | | 4- | hexylresorcinol | | 4-N- | hexylresorcinol | | p- | hexylresorcinol | | | sucrets | | | worm-agen |
Articles:
| PubMed:Silk fibroin and 4-hexylresorcinol incorporation membrane for guided bone regeneration. |
| PubMed:4-hexylresorcinol exerts antitumor effects via suppression of calcium oscillation and its antitumor effects are inhibited by calcium channel blockers. |
| PubMed:Cisplatin and 4-hexylresorcinol synergise to decrease metastasis and increase survival rate in an oral mucosal melanoma xenograft model: a preliminary study. |
| PubMed:4-n-butylresorcinol, a highly effective tyrosinase inhibitor for the topical treatment of hyperpigmentation. |
| PubMed:4-hexylresorcinol stimulates the differentiation of SCC-9 cells through the suppression of E2F2, E2F3 and Sp3 expression and the promotion of Sp1 expression. |
| PubMed:Comparison of the simple cyclic voltammetry (CV) and DPPH assays for the determination of antioxidant capacity of active principles. |
| PubMed:4-hexylresorcinol inhibits NF-κB phosphorylation and has a synergistic effect with cisplatin in KB cells. |
| PubMed:Aerosol deposition of hydroxyapatite and 4-hexylresorcinol coatings on titanium alloys for dental implants. |
| PubMed:Differential tissue distribution and specificity of phenoloxidases from the Pacific oyster Crassostrea gigas. |
| PubMed:A measurement of the unstirred aqueous boundary layer in a Franz diffusion cell. |
| PubMed:Edible mushroom (Flammulina velutipes) extract inhibits melanosis in Kuruma shrimp (Marsupenaeus japonicus). |
| PubMed:[Effect of chemical chaperones on properties of lysozyme and the reaction center protein from Rhodobacter sphaeroides]. |
| PubMed:4-Hexylresorcinol inhibits transglutaminase-2 activity and has synergistic effects along with cisplatin in KB cells. |
| PubMed:First evidence of laccase activity in the Pacific oyster Crassostrea gigas. |
| PubMed:Variations in IC(50) values with purity of mushroom tyrosinase. |
| PubMed:Effect of natural antibrowning agents on color and related enzymes in fresh-cut Fuji apples as an alternative to the use of ascorbic acid. |
| PubMed:Identification of xenoestrogens in food additives by an integrated in silico and in vitro approach. |
| PubMed:Effect of pyrophosphate and 4-hexylresorcinol pretreatment on quality of refrigerated white shrimp (Litopenaeus vannamei) kept under modified atmosphere packaging. |
| PubMed:Solvent effects on the spectroscopic properties of 4-hexylresorcinol. |
| PubMed:Browning prevention by ascorbic acid and 4-hexylresorcinol: different mechanisms of action on polyphenol oxidase in the presence and in the absence of substrates. |
| PubMed:Ascorbic acid and 4-hexylresorcinol effects on pear PPO and PPO catalyzed browning reaction. |
| PubMed:Oxyresveratrol as an antibrowning agent for cloudy apple juices and fresh-cut apples. |
| PubMed:Use of experimental design methodology to prepare Maillard reaction products from glucose and cysteine inhibitors of polyphenol oxidase from eggplant (Solanum melongena). |
| PubMed:[Determination of 4-hexylresorcinol residues in prawns and crabs]. |
| PubMed:Role of sulfites and 4-hexylresorcinol in microbial growth and melanosis prevention of deepwater pink shrimp (Parapenaeus longirostris) using a controlled atmosphere. |
| PubMed:Effects of resveratrol and 4-hexylresorcinol on hydrogen peroxide-induced oxidative DNA damage in human lymphocytes. |
| PubMed:Polyphenol oxidases from latex of Hevea brasiliensis: purification and characterization. |
| PubMed:Maintaining quality of fresh-cut mangoes using antibrowning agents and modified atmosphere packaging. |
| PubMed:Cytokine release and cytotoxicity in human keratinocytes and fibroblasts induced by phenols and sodium dodecyl sulfate. |
| PubMed:Characterization of catecholase and cresolase activities of eggplant polyphenol oxidase. |
| PubMed:Determination of 4-hexylresorcinol in shrimp by liquid chromatography with fluorescence detection. |
| PubMed:Influence of pH, benzoic acid, glutathione, EDTA, 4-hexylresorcinol, and sodium chloride on the pressure inactivation kinetics of mushroom polyphenol oxidase. |
| PubMed:Oxidation of the flavonol quercetin by polyphenol oxidase. |
| PubMed:Extending storage life of fresh-cut apples using natural products and their derivatives. |
| PubMed:Oxidation of the flavonol fisetin by polyphenol oxidase. |
| PubMed:4-Hexylresorcinol as inhibitor of shrimp melanosis: efficacy and residues studies; evaluation of possible toxic effect in a human intestinal in vitro model (Caco-2); preliminary safety assessment. |
| PubMed:Determination of 4-hexylresorcinol in crab meat. |
| PubMed:Liquid chromatographic determination of the processing aid 4-hexylresorcinol in shrimp. |
| PubMed:Generally recognized as safe (GRAS) evaluation of 4-hexylresorcinol for use as a processing aid for prevention of melanosis in shrimp. |
| PubMed:Does everything "cause" cancer: an alternative interpretation of the "carcinogenesis" bioassay. |
| PubMed:Development and validation of a cellular transplant model for leukemia in Fischer rats: a short-term assay for potential anti-leukemic chemicals. |
| PubMed:Inhibition of some spontaneous tumors by 4-hexylresorcinol in F344/N rats and B6C3F1 mice. |
| PubMed:NTP Toxicology and Carcinogenesis Studies of 4-Hexylresorcinol (CAS No. 136-77-6) in F344/N Rats and B6C3F1 Mice (Gavage Studies). |
| PubMed:Genotoxicity of amebicide and anthelmintic drugs in Escherichia coli pol A+/pol A-. |
| PubMed:Prediction of solubility in nonideal multicomponent systems using the UNIFAC group contribution model. |
| PubMed:Mutagenicity of antiamebic and anthelmintic drugs in the Salmonella typhimurium microsomal test system. |
| PubMed:Solubility behavior of phenolic compounds in hexane-ethyl acetate, hexane-ethyl myristate, and hexane-ethyl pivalate cosolvent systems. |
| PubMed:Effect of complex formation between 4-hexylresorcinol and ethyl myristate on release rate of 4-hexylresorcinol from petrolatum base. |
| PubMed:Review of the 4-hexylresorcinol procedure for acrolein analysis. |
| PubMed:[Determination of acrolein in the air by means of its reaction with 4-hexylresorcinol]. |
| PubMed:The use of acid dissociation constants in selecting buffers to effect the electrophoretic separation of bithionol, fenticlor, hexachlorophene, bromchlorophene, dichlorophene, tetrachlorophene and 4-hexylresorcinol. |
| PubMed:[Experimental anticancer studies. II. On the anti-tumor effect of 6-(2'-hydroxy-3', 5'-dihalophenylazo)-4-hexylresorcinol and related compounds on Yoshida sarcoma and Ehrlich ascites carcinoma in vivo]. |
| PubMed:Experimental anticancer studies. I. The preparation of 6-(2'-hydroxy-3', 5'-dibromophenylazo)-4-hexylresorcinol and related compounds, with brief reference to their anticancer activity. |
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3D/inchi