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Category:propellants, aerating agents, and gas
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | colorless gas (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | -157.42 °C. @ 760.00 mm Hg (est)
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| Boiling Point: | -38.10 °C. @ 760.00 mm Hg (est)
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| Vapor Pressure: | 7250.000000 mmHg @ 25.00 °C. (est) |
| Vapor Density: | 3 ( Air = 1 ) |
| Flash Point: | -129.00 °F. TCC ( -89.40 °C. ) (est)
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| logP (o/w): | 1.080 |
| Soluble in: |
| | water, 2770 mg/L @ 25 °C (exp) | | | water, 2748 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD > 43200 ug/kg Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 48(8), Pg. 69, 1983.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
inhalation-dog LCLo 70 pph LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES Toxicology and Applied Pharmacology. Vol. 2, Pg. 363, 1960.
inhalation-guinea pig LCLo 30 pph/2H BEHAVIORAL: GENERAL ANESTHETIC
BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. Vol. 21, Pg. 149, 1971.
inhalation-mouse LC50 1380000 mg/m3/2H LUNGS, THORAX, OR RESPIRATION: CYANOSIS
BEHAVIORAL: ATAXIA
BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. Vol. 75, Pg. 241, 1963.
inhalation-rat LC50 35 pph/15M LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
BEHAVIORAL: ATAXIA Human Toxicology. Vol. 1, Pg. 239, 1982.
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Safety in Use Information:
| Category: | | propellants, aerating agents, and gas |
| Recommendation for hydrochlorofluorocarbon 22 usage levels up to: | | | not for fragrance use.
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| Recommendation for hydrochlorofluorocarbon 22 flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | algeon 22 | | | algofrene 22 | | | algofrene type 6 | | | arcton 22 | | | arcton 4 | | | CFC 22 | | | chloro(difluoro)methane | | | chlorodifluoromethane | | mono- | chlorodifluoromethane | | | chlorodifluoromethane [R22] [UN1018] [Nonflammable gas] | | | chlorofluorocarbon 22 | | | daiflon 22 | | | difluorochloromethane | | | difluoromonochloromethane | | | dymel 22 | | | electro-CF 22 | | | eskimon 22 | | | F 22 (halocarbon) | | | FC 22 | | | FKW 22 | | | flugene 22 | | | fluorocarbon-22 | | | forane 22 | | | forane 22 B | | | freon 22 | | | frigen 22 | | | genetron 22 | | | haltron 22 | | | HCFC 22 | | | HCFC-22 | | | HFA-22 | | | HSDB 143 | | | isceon 22 | | | isotron 22 | | | khladon 22 | | | methane, chlorodifluoro- | | | propellant 22 | | | R 22 (refrigerant) | | | racon 22 | | | refrigerant R 22 | | | ucon 22 |
Articles:
| PubMed:Asphyxiation fatality exposure from chlorodifluoromethane. |
| PubMed:Determination of partition coefficients of refrigerants by gas liquid chromatographic headspace analysis. |
| PubMed:High-temperature hydrodechlorination of ozone-depleting chlorodifluoromethane (HCFC-22) on supported Pd and Ni catalysts. |
| PubMed:The structure and interaction energies of the weak complexes of CHClF2 and CHF3 with HCCH: a test of density functional theory methods. |
| PubMed:'Virgin gas' ban demands user rethink. |
| PubMed:[Determination of chlorodifluoromethane in air of work places with gas chromatography]. |
| PubMed:An improved system for exposure of cultured mammalian cells to gaseous compounds in the chromosomal aberration assay. |
| PubMed:Difluoromethyltrialkylammonium salts--their expeditious synthesis from chlorodifluoromethane and tertiary amines in the presence of concentrated aqueous sodium hydroxide. The catalytic process. |
| PubMed:Simultaneous conversion of CHClF(2) and CH(3)Br to CH(2)CF(2). |
| PubMed:An accidental death due to Freon 22 (monochlorodifluoromethane) inhalation in a fishing vessel. |
| PubMed:Jet spectroscopy of arylmethyl radicals in the visible region: assignment of low-frequency vibrational modes in diphenylmethyl and chlorodiphenylmethyl radicals. |
| PubMed:Acute inhalational exposure to chlorodifluoromethane (freon-22): a report of 43 cases. |
| PubMed:Quantification of the refrigerants R22 and R134a in mixtures by means of different polymers and reflectometric interference spectroscopy. |
| PubMed:Inhalation of decomposed chlorodifluoromethane (freon-22) and myocardial infarction. |
| PubMed:Improper or classical hydrogen bonding? A comparative cryosolutions infrared study of the complexes of HCClF(2), HCCl(2)F, and HCCl(3) with dimethyl ether. |
| PubMed:[Measurement of chlorodifluoromethane(HCFC-22) in the atmosphere by using an O2-induced electron capture detector (ECD)]. |
| PubMed:In situ X-ray diffraction and solid-state NMR study of the fluorination of gamma-Al(2)O(3) with HCF(2)Cl. |
| PubMed:A sensitive neutron dosimeter using superheated liquid. |
| PubMed:Formation of phosgene during welding activities in an atmosphere containing chlorinated hydrocarbons. |
| PubMed:Chlorodifluoromethane. |
| PubMed:Frigen II improves the reliability of measurement of interleukin-1 related substances in amniotic fluid. |
| PubMed:Facial injury and airway threat from inhalant abuse: a case report. |
| PubMed:Cryogen spray cooling during Nd:YAG laser treatment of hemangiomas. A preliminary animal model study. |
| PubMed:Nd:YAG laser irradiation in conjunction with cryogen spray cooling induces deep and spatially selective photocoagulation in animal models. |
| PubMed:The influence of sleeping position on functional residual capacity and effective pulmonary blood flow in healthy neonates. |
| PubMed:Headspace GC/MS testing for chlorodifluoromethane in two fatal cases. |
| PubMed:Secondary arterial hypertension linked to Freon exposure. |
| PubMed:Occupational phosgene poisoning: a case report and review. |
| PubMed:Evaluation of sampling and analytical methods for the determination of chlorodifluoromethane in air. |
| PubMed:Fatality due to recreational use of chlorodifluoromethane and chloropentafluoroethane. |
| PubMed:[Sudden death caused by freon 22?]. |
| PubMed:Human inhalation pharmacokinetics of chlorodifluoromethane (HCFC22). |
| PubMed:Comparison of estimates of cardiac output by indicator dilution and freon 22 uptake during gas mixing in dogs. |
| PubMed:[Temperature profile in the enamel during cold tests]. |
| PubMed:Behavioural thermoregulation in mice: effects of low doses of general anaesthetics of different potency. |
| PubMed:Acute toxicity of a nuclear magnetic resonance cerebral blood flow indicator in cats. |
| PubMed:Sloping alveolar plateaus of CO2, O2, and intravenously infused C2H2 and CHClF2 in the dog. |
| PubMed:Cooling rate and ice-crystal measurement in biological specimens plunged into liquid ethane, propane, and Freon 22. |
| PubMed:Expirograms of O2, CO2 and intravenously infused C2H2 and Freon-22 during panting in dogs. |
| PubMed:Cardiac arrhythmia in refrigerator repairmen exposed to fluorocarbons. |
| PubMed:Cardiac arrhythmias during occupational exposure to fluorinated hydrocarbons. |
| PubMed:Effects of environmental O2 on blood flow and diffusing capacity in amphibian skin. |
| PubMed:Solubility of Freon 22 in human blood and lung tissue. |
| PubMed:Solubility of freon-22 in blood and lung tissue. |
| PubMed:The sloping alveolar plateau of tracer gases washed out from mixed venous blood in man. |
| PubMed:Cerebral blood flow measured by NMR indicator dilution in cats. |
| PubMed:[A toxicological study of the effects of freon 22 inhalation--the behavior of rats exposed to freon inhalation and an evaluation of freon concentrations in their tissue]. |
| PubMed:Elimination kinetics of acetylene and Freon 22 in resting and active lungless salamanders. |
| PubMed:Long-term carcinogenicity bioassays on three chlorofluorocarbons (trichlorofluoromethane, FC11; dichlorodifluoromethane, FC12; chlorodifluoromethane, FC22) administered by inhalation to Sprague-Dawley rats and Swiss mice. |
| PubMed:Diffusion-related differences in elimination of inert gases from the lung. |
| PubMed:Different pharmacokinetics of dichlorofluoromethane (CFC 21) and chlorodifluoromethane (CFC 22). |
| PubMed:Chlorodifluoromethane. |
| PubMed:The relevance for man of animal data on reproductive toxicity of industrial chemicals. |
| PubMed:[Effects of the use of FRIGEN (AG-Ffm-HOECST) on the determination of blood levels of some proteins (IgA, IgM, IgG, C3c, C4) in cord blood of healthy newborn infants at term by laser nephelometry]. |
| PubMed:The toxicological evaluation of chlorofluorocarbon 22 (CFC 22). |
| PubMed:Role of diffusion-dependent gas inhomogeneity in gas exchange in the dog. |
| PubMed:Acute toxicity of fluorocarbon-22: toxic symptoms, lethal concentration, and its fate in rabbit and mouse. |
| PubMed:Studies on the male reproductive toxicity of Freon 22. |
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