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Category:cosmetic ingredient for skin conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Appearance: | orange crystalline powder (est) |
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Melting Point: | 257.00 °C. @ 760.00 mm Hg
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| Boiling Point: | 586.87 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 613.00 °F. TCC ( 322.80 °C. ) (est)
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| logP (o/w): | 3.641 (est) |
| Soluble in: |
| | water, 2.042 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intraperitoneal-mouse LD50 35 mg/kg
GASTROINTESTINAL: OTHER CHANGES
Journal of Agricultural and Food Chemistry. Vol. 27, Pg. 1342, 1979.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic ingredient for skin conditioning |
| Recommendation for emodin usage levels up to: | | | not for fragrance use.
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| Recommendation for emodin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
References:
| | 1,3,8-trihydroxy-6-methylanthracene-9,10-dione |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 3220 |
| Pubchem (sid): | 134976663 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| 9,10- | anthracenedione, 1,3,8-trihydroxy-6-methyl- | | 9,10- | anthracenedione, 1,3,8-trihydroxy-6-methyl- (9CI) | | | anthraquinone, 1,3,8-trihydroxy-6-methyl- (8CI) | | | anthraquinone, 6-methyl-1,3,8-trihydroxy- | | | emodol | | | frangula emodin | | | frangulic acid | | 6- | methyl-1,3,8-trihydroxy-9,10-anthracenedione | | 3- | methyl-1,6, 8-trihydroxyanthraquinone | | 3- | methyl-1,6,8-trihydroxyanthraquinone | | | rheum emodin | | 4,5,7- | trihydroxy-2-methylanthraquinone | | 1,6,8- | trihydroxy-3-methylanthracene-9,10-dione | | 1,3,8- | trihydroxy-6-methyl-9,10-anthracenedione | | 1,3,8- | trihydroxy-6-methyl-9,10-anthraquinone | | 1,3,8- | trihydroxy-6-methyl-9,10-dihydroanthracene-9,10-dione | | 1,3,8- | trihydroxy-6-methyl-anthraquinone | | 1,3,8- | trihydroxy-6-methylanthra-9,10-quinone | | 1,3,8- | trihydroxy-6-methylanthracene-9,10-dione | | 1,3,8- | trihydroxy-6-methylanthraquinone |
Articles:
| PubMed:Development of an improved reverse-phase high-performance liquid chromatography method for the simultaneous analyses of trans-/cis-resveratrol, quercetin, and emodin in commercial resveratrol supplements. |
| PubMed:Polysaccharides from dioscorea ( shān yào) and other phytochemicals enhance antitumor effects induced by DNA vaccine against melanoma. |
| PubMed:[Simultaneous determination of 25 illegally added drugs in diet health foods by ultra-high performance liquid chromatography]. |
| PubMed:In vitro anti-osteoporosis properties of diverse Korean Drynariae rhizoma phenolic extracts. |
| PubMed:Emodin attenuates systemic and liver inflammation in hyperlipidemic mice administrated with lipopolysaccharides. |
| PubMed:[Effect of emodin lipid nano-microbubble on MAPK signal pathway and inflammation cytokine in AT-II cells by mechanical stretch]. |
| PubMed:Molecular approaches toward targeted cancer prevention with some food plants and their products: inflammatory and other signal pathways. |
| PubMed:Optimized ultrasound-assisted extraction of phenolic compounds from Polygonum cuspidatum. |
| PubMed:Emodin represses TWIST1-induced epithelial-mesenchymal transitions in head and neck squamous cell carcinoma cells by inhibiting the β-catenin and Akt pathways. |
| PubMed:Novel molecularly imprinted polymers with carbon nanotube as matrix for selective solid-phase extraction of emodin from kiwi fruit root. |
| PubMed:Chemical constituents of Aloe barbadensis Miller and their inhibitory effects on phosphodiesterase-4D. |
| PubMed:Quality assessment of Japanese knotweed (Fallopia japonica) grown on Prince Edward Island as a source of resveratrol. |
| PubMed:Is it possible to increase the aloin content of Aloe vera by the use of ultraviolet light? |
| PubMed:Rapid and simple method for the determination of emodin in tartary buckwheat (Fagopyrum tataricum) by high-performance liquid chromatography coupled to a diode array detector. |
| PubMed:Emodin-6-O-β-D-glucoside inhibits HMGB1-induced inflammatory responses in vitro and in vivo. |
| PubMed:Anthraquinone profile, antioxidant and antimicrobial activity of bark extracts of Rhamnus alaternus, R. fallax, R. intermedia and R. pumila. |
| PubMed:Ultrasonic-assisted extraction of the botanical dietary supplement resveratrol and other constituents of Polygonum cuspidatum. |
| PubMed:Isolation and identification of Flavobacterium columnare and Streptococcus iniae antibacterial compounds from the terrestrial plant Atraphaxis laetevirens. |
| PubMed:Assessment of antibacterial properties and the active ingredient of plant extracts and its effect on the performance of crucian carp (Carassius auratus gibelio var. E'erqisi, Bloch). |
| PubMed:Comment on "The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells by Zhu et al. (2012). |
| PubMed:Cell-type dependent response of melanoma cells to aloe emodin. |
| PubMed:Aloe-emodin inhibits adipocyte differentiation and maturation during in vitro human mesenchymal stem cell adipogenesis. |
| PubMed:Effects of an anthraquinone derivative from Rheum officinale Baill, emodin, on airway responses in a murine model of asthma. |
| PubMed:Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: roles of apoptotic cell death and LS1034 tumor xenografts model. |
| PubMed:Involvement of pachybasin and emodin in self-regulation of Trichoderma harzianum mycoparasitic coiling. |
| PubMed:Protective effects of emodin against cisplatin-induced oxidative stress in cultured human kidney (HEK 293) cells. |
| PubMed:Anthraquinones of Cissus populnea Guill & Perr (Amplidaceae). |
| PubMed:The endoplasmic reticulum stress response is involved in apoptosis induced by aloe-emodin in HK-2 cells. |
| PubMed:Microwave-assisted extraction performed in low temperature and in vacuo for the extraction of labile compounds in food samples. |
| PubMed:Hepatoprotection of emodin and Polygonum multiflorum against CCl(4)-induced liver injury. |
| PubMed:Single-kernel analysis of fumonisins and other fungal metabolites in maize from South African subsistence farmers. |
| PubMed:Protective Effects of Emodin and Chrysophanol Isolated from Marine Fungus Aspergillus sp. on Ethanol-Induced Toxicity in HepG2/CYP2E1 Cells. |
| PubMed:Development of a liquid chromatography tandem mass spectrometry method for simultaneous determination of eight adulterants in slimming functional foods. |
| PubMed:A new cytotoxic indole-3-ethenamide from the halotolerant fungus Aspergillus sclerotiorum PT06-1. |
| PubMed:Comparison of the antioxidant and transmembrane permeative activities of the different Polygonum cuspidatum extracts in phospholipid-based microemulsions. |
| PubMed:Fungal community associated with fermentation and storage of Fuzhuan brick-tea. |
| PubMed:Dietary aloin, aloesin, or aloe-gel exerts anti-inflammatory activity in a rat colitis model. |
| PubMed:A novel sensitive detection platform for antitumor herbal drug aloe-emodin based on the graphene modified electrode. |
| PubMed:The effect of emodin, an anthraquinone derivative extracted from the roots of Rheum tanguticum, against herpes simplex virus in vitro and in vivo. |
| PubMed:Influence of carbon source on growth and mycotoxin production by isolates of Pyrenophora tritici-repentis from wheat. |
| PubMed:Effects of food and gender on the pharmacokinetics of rhein and emodin in rats after oral dosing with Da-Cheng-Qi decoction. |
| PubMed:Alaternin attenuates delayed neuronal cell death induced by transient cerebral hypoperfusion in mice. |
| PubMed:The metabolic benefits of Polygonum hypoleucum Ohwi in HepG2 cells and Wistar rats under lipogenic stress. |
| PubMed:Redotex ingestions reported to Texas poison centers. |
| PubMed:Intestinal absorption of aloin, aloe-emodin, and aloesin; A comparative study using two in vitro absorption models. |
| PubMed:Anti-diabetic effects of emodin involved in the activation of PPARgamma on high-fat diet-fed and low dose of streptozotocin-induced diabetic mice. |
| PubMed:Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. |
| PubMed:Emodin induces apoptosis of human tongue squamous cancer SCC-4 cells through reactive oxygen species and mitochondria-dependent pathways. |
| PubMed:Equivocal colonic carcinogenicity of Aloe arborescens Miller var. natalensis berger at high-dose level in a Wistar Hannover rat 2-y study. |
| PubMed:Structure-activity relationships of anthraquinones on the suppression of DNA-binding activity of the aryl hydrocarbon receptor induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin. |
| PubMed:Influence of water activity and temperature on growth and mycotoxin production by isolates of Pyrenophora tritici-repentis from wheat. |
| PubMed:Multiple compounds determination and fingerprint analysis of Lidanpaishi tablet and keli by high-performance liquid chromatography. |
| PubMed:Anti-angiogenic effects of rhubarb and its anthraquinone derivatives. |
| PubMed:Inhibitory activities of Cassia tora and its anthraquinone constituents on angiotensin-converting enzyme. |
| PubMed:Effect of a polyphenol-rich extract from Aloe vera gel on experimentally induced insulin resistance in mice. |
| PubMed:Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay. |
| PubMed:Aloe-emodin-induced apoptosis in human gastric carcinoma cells. |
| PubMed:Chemical constituents of cape aloe and their synergistic growth-inhibiting effect on Ehrlich ascites tumor cells. |
| PubMed:Photo-irradiation of Aloe vera by UVA--formation of free radicals, singlet oxygen, superoxide, and induction of lipid peroxidation. |
| PubMed:Rapid separation and determination of structurally related anthraquinones in Rhubarb by pressurized capillary electrochromatography. |
| PubMed:Aloe-emodin induces apoptosis in T24 human bladder cancer cells through the p53 dependent apoptotic pathway. |
| PubMed:Effect of inhibition of aloe-emodin on N-acetyltransferase activity and gene expression in human malignant melanoma cells (A375.S2). |
| PubMed:Antigenotoxic properties of Cassia tea (Cassia tora L.): mechanism of action and the influence of roasting process. |
| PubMed:Anthraquinones isolated from Cassia tora (Leguminosae) seed show an antifungal property against phytopathogenic fungi. |
| PubMed:Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin. |
| PubMed:Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. |
| PubMed:Emodin isolated from Cassia obtusifolia (Leguminosae) seed shows larvicidal activity against three mosquito species. |
| PubMed:Flavonoids as aryl hydrocarbon receptor agonists/antagonists: effects of structure and cell context. |
| PubMed:Rubratoxin B induced the secretion of hepatic injury-related colony stimulating factors in human hepatoma cells. |
| PubMed:Spoilage fungi and their mycotoxins in commercially marketed chestnuts. |
| PubMed:Cynodontin: a fungal metabolite with antifungal properties. |
| PubMed:In vitro studies on the photobiological properties of aloe emodin and aloin A. |
| PubMed:[Contents of barbaloin-related compounds in aloe drinks and their change during storage]. |
| PubMed:Aloe exudate: characterization by reversed phase HPLC and headspace GC-MS. |
| PubMed:Hepatotoxin rubratoxin B induced the secretion of TNF-alpha, IL-8, and MCP-1 in HL60 cells. |
| PubMed:Inhibitory effects of Cassia tora L. on benzo[a]pyrene-mediated DNA damage toward HepG2 cells. |
| PubMed:Comparative evaluation of antioxidant potential of alaternin (2-hydroxyemodin) and emodin. |
| PubMed:Cytochrome P4501A1-inhibitory action of antimutagenic anthraquinones in medicinal plants and the structure-activity relationship. |
| PubMed:Occurrence of emodin, chrysophanol and physcion in vegetables, herbs and liquors. Genotoxicity and anti-genotoxicity of the anthraquinones and of the whole plants. |
| PubMed:Studies on toxigenic fungi in roasted foodstuff (salted seed) and halotolerant activity of emodin-producing Aspergillus wentii. |
| PubMed:Inhibitory actions of emodin on arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients. |
| PubMed:Genotoxicity of the laxative drug components emodin, aloe-emodin and danthron in mammalian cells: topoisomerase II mediated? |
| PubMed:High-performance liquid chromatographic profiles of aloe constituents and determination of aloin in beverages, with reference to the EEC regulation for flavouring substances. |
| PubMed:Alaternin, cassiaside and rubrofusarin gentiobioside, radical scavenging principles from the seeds of Cassia tora on 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. |
| PubMed:Toxicity of structurally related anthraquinones and anthrones to mammalian cells in vitro. |
| PubMed:Effect of emodin on cooked-food mutagen activation. |
| PubMed:Genotoxicity testing of arsenobetaine, the predominant form of arsenic in marine fishery products. |
| PubMed:Occurrence and detection of natural mutagens and modifying factors in food products. |
| PubMed:[Occurrence and analysis of the mycotoxin emodin]. |
| PubMed:Determination of emodin in feeds. |
| PubMed:Emodin, a toxic metabolite of Aspergillus wentii isolated from weevil-damaged chestnuts. |
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purgative anthraquinone found in several plants, especially rhamnus frangula. it was formerly used as a laxative, but is now used mainly as tool in toxicity studies. Present in Cascara sagrada
Emodin is a purgative resin from rhubarb, Polygonum cuspidatum, the buckthorn and Japanese Knotweed (Fallopia japonica). The term may also refer to any one of a series of principles isomeric with the emodin of rhubarb. (Wikipedia)
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3D/inchi
