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Category:cosmetic ingredient for hair conditioning
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
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| Food Chemicals Codex Listed: | No |
| Boiling Point: | 1128.50 °C. @ 760.00 mm Hg (est)
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| Flash Point: | 1177.00 °F. TCC ( 636.30 °C. ) (est)
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| logP (o/w): | 7.193 (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
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| Hazards identification |
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| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
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| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
intravenous-rat LD50 43 mg/kg
KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION
BLOOD: HEMORRHAGE
Toxicology Letters. Vol. 2, Pg. 329, 1978.
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| Dermal Toxicity: |
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Not determined
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| Inhalation Toxicity: |
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Not determined
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Safety in Use Information:
| Category: | | cosmetic ingredient for hair conditioning |
| Recommendation for hematin usage levels up to: | | | not for fragrance use.
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| Recommendation for hematin flavor usage levels up to: |
| | not for flavor use.
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Safety References:
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :27337 |
| National Institute of Allergy and Infectious Diseases:Data |
| WGK Germany:3 |
| 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate |
| Chemidplus:0015489904 |
| RTECS:NO6725000 for cas# 15489-90-4 |
References:
| | 3-[18-(2-carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate |
| NIST Chemistry WebBook: | Search Inchi |
| Pubchem (cid): | 27337 |
| Pubchem (sid): | 134992696 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | dihydrogen hydroxy(3,8,13,17-tetramethyl-7,12-divinyl-21H,23H-porphine-2,18-dipropionato(4-)-n21,n22,n23,n24)ferrate(2-) | | | hematin from bovine blood | | 3-[18-(2- | carboxyethyl)-8,13-bis(ethenyl)-3,7,12,17-tetramethylporphyrin-21,24-diid-2-yl]propanoic acid;iron(2+);hydrate | | | ferrihemate | | | ferriheme | | | haematin | | | hydroxo(protoporphyrinato)iron(III) | | | hydroxo[3,7,12,17-tetramethyl-8,13-divinylporphyrin-2,18-dipropanoato(2-)]iron(III) | | | hydroxy(dihydrogen protoporphyrin IX-ato(2-))iron | | | hydroxyhemin | | | iron, (dihydrogen 3,7,12,17-tetramethyl-8,13-divinyl-2,18-porphinedipropionato(2-))-hydroxy- | | | phenodin | | | protohematin |
Articles:
| PubMed:Blood meal-based compound. Good choice as iron fertilizer for organic farming. |
| PubMed:Hemozoin accumulation in Garnham bodies of Plasmodium falciparum gametocytes. |
| PubMed:Erythrocyte membranes convert monomeric ferriprotoporphyrin IX to β-hematin in acidic environment at malarial fever temperature. |
| PubMed:Dietary iron-initiated lipid oxidation and its inhibition by polyphenols in gastric conditions. |
| PubMed:Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study. |
| PubMed:Toward understanding the chloroquine action at the molecular level in antimalarial therapy--X-ray absorption studies in acetic acid solution. |
| PubMed:Factors in various fractions of meat homogenates that affect the oxidative stability of raw chicken breast and beef loin. |
| PubMed:Physicochemical properties, pharmacokinetics, and pharmacodynamics of intravenous hematin: a literature review. |
| PubMed:Interactions between antiplasmodial 3,6-diamino-1'-dimethyl-9-anilinoacridine and hematin and concanamycin A. |
| PubMed:The mechanism of antimalarial action of the ruthenium(II)-chloroquine complex [RuCl(2)(CQ)] (2). |
| PubMed:Alcohols induce beta-hematin formation via the dissociation of aggregated heme and reduction in interfacial tension of the solution. |
| PubMed:Malaria hemozoin is immunologically inert but radically enhances innate responses by presenting malaria DNA to Toll-like receptor 9. |
| PubMed:Structural analysis of the anti-malaria active agent chloroquine under physiological conditions. |
| PubMed:Antimalarial drugs inhibiting hemozoin (beta-hematin) formation: a mechanistic update. |
| PubMed:Resonance Raman spectroscopy in malaria research. |
| PubMed:Insights into the mechanism of action of ferroquine. Relationship between physicochemical properties and antiplasmodial activity. |
| PubMed:Synthesis of some cryptolepine analogues, assessment of their antimalarial and cytotoxic activities, and consideration of their antimalarial mode of action. |
| PubMed:A colorimetric high-throughput beta-hematin inhibition screening assay for use in the search for antimalarial compounds. |
| PubMed:1,4-bis(3-aminopropyl)piperazine libraries: from the discovery of classical chloroquine-like antimalarials to the identification of new targets. |
| PubMed:Inhibition of glutathione S-transferases by thonningianin A, isolated from the African medicinal herb, Thonningia sanguinea, in vitro. |
| PubMed:Raman imaging of hemozoin within the food vacuole of Plasmodium falciparum trophozoites. |
| PubMed:Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position. |
| PubMed:Concentration effects in myoglobin-catalyzed peroxidation of linoleate. |
| PubMed:On the mechanism of hemozoin production in malaria parasites: activated erythrocyte membranes promote beta-hematin synthesis. |
| PubMed:Generation of lipid peroxyl radicals from edible oils and their biological activities: a need for consideration for anti-radical components and purification processing. |
| PubMed:Characterization of chloroquine-hematin mu-oxo dimer binding by isothermal titration calorimetry. |
| PubMed:Phagocytosis of hemozoin (native and synthetic malaria pigment), and Plasmodium falciparum intraerythrocyte-stage parasites by human and mouse phagocytes. |
| PubMed:Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity. |
| PubMed:Structural specificity of chloroquine-hematin binding related to inhibition of hematin polymerization and parasite growth. |
| PubMed:Deferoxamine: stimulation of hematin polymerization and antagonism of its inhibition by chloroquine. |
| PubMed:Role of glutathione in the detoxification of ferriprotoporphyrin IX in chloroquine resistant Plasmodium berghei. |
| PubMed:The ultrastructure of the gastrodermis and the nutrition of the gill parasitic Atriaster heterodus Lebedev and Paruchin, 1969 (Platyhelminthes: Monogenea). |
| PubMed:Access to hematin: the basis of chloroquine resistance. |
| PubMed:The iron environment in heme and heme-antimalarial complexes of pharmacological interest. |
| PubMed:High-performance liquid chromatographic analysis of biological and chemical heme polymerization. |
| PubMed:Influence of pH, salt and nitrite on the heme-dependent catalase activity of lactic acid bacteria. |
| PubMed:Heme-dependent catalase activity of lactobacilli. |
| PubMed:Biochemical characterization of Plasmodium falciparum hemozoin. |
| PubMed:Generation of reactive intermediates from the tumor promoter butylated hydroxytoluene hydroperoxide in isolated murine keratinocytes or by hematin. |
| PubMed:Isolation and enumeration of Campylobacter jejuni from poultry products by a selective enrichment method. |
| PubMed:Protein changes in frozen fish. |
| PubMed:Phagotrophy and two new structures in the malaria parasite Plasmodium berghei. |
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3D/inchi
