| Name: | 2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane |
| CAS Number: | 556-67-2 |  3D/inchi
|
| Other(deleted CASRN): | 104986-37-0 |
| ECHA EINECS - REACH Pre-Reg: | 209-136-7 |
| FDA UNII: | CZ227117JE |
| Nikkaji Web: | J428F |
| Beilstein Number: | 1787074 |
| MDL: | MFCD00003269 |
| Molecular Weight: | 296.61728000 |
| Formula: | C8 H24 O4 Si4 |
| BioActivity Summary: | listing |
| NMR Predictor: | Predict (works with chrome, Edge or firefox) |
Category:cosmetic agents
US / EU / FDA / JECFA / FEMA / FLAVIS / Scholar / Patent Information:
Physical Properties:
| Assay: | 95.00 to 100.00
|
| Food Chemicals Codex Listed: | No |
| Specific Gravity: | 0.95600 @ 25.00 °C.
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| Refractive Index: | 1.39600 @ 20.00 °C.
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| Melting Point: | 17.50 °C. @ 760.00 mm Hg
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| Boiling Point: | 175.80 °C. @ 760.00 mm Hg
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| Vapor Pressure: | 1.600000 mmHg @ 25.00 °C. (est) |
| Flash Point: | 140.00 °F. TCC ( 60.00 °C. )
|
| logP (o/w): | 5.100 |
| Soluble in: |
| | water, 0.005 mg/L @ 25 °C (exp) | | | water, 0.06124 mg/L @ 25 °C (est) |
Organoleptic Properties:
| Odor and/or flavor descriptions from others (if found). |
Cosmetic Information:
Suppliers:
Safety Information:
| Preferred SDS: View |
| |
| Hazards identification |
| |
| Classification of the substance or mixture |
| GHS Classification in accordance with 29 CFR 1910 (OSHA HCS) |
| None found. |
| GHS Label elements, including precautionary statements |
| |
| Pictogram | |
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| Hazard statement(s) |
| None found. |
| Precautionary statement(s) |
| None found. |
| Oral/Parenteral Toxicity: |
oral-rat LD50 1540 mg/kg
BEHAVIORAL: TREMOR
National Technical Information Service. Vol. OTS0538262
|
| Dermal Toxicity: |
skin-rabbit LD50 794 uL/kg
KIDNEY, URETER, AND BLADDER: HEMATURIA
National Technical Information Service. Vol. OTS0538262
skin-rat LD50 1770 mg/kg
BEHAVIORAL: TREMOR
GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS
LIVER: OTHER CHANGES
National Technical Information Service. Vol. OTS0538262
|
| Inhalation Toxicity: |
inhalation-rat LC50 36000 mg/m3/4H
LUNGS, THORAX, OR RESPIRATION: DYSPNEA
BEHAVIORAL: EXCITEMENT
SKIN AND APPENDAGES (SKIN): HAIR: OTHER
National Technical Information Service. Vol. OTS0557551
|
Safety in Use Information:
| Category: | | cosmetic agents |
| Recommendation for octamethyl cyclotetrasiloxane usage levels up to: | | | not for fragrance use.
|
| |
| Recommendation for octamethyl cyclotetrasiloxane flavor usage levels up to: |
| | not for flavor use.
|
Safety References:
| EPI System: View |
| NIOSH International Chemical Safety Cards:search |
| Chemical Carcinogenesis Research Information System:Search |
| AIDS Citations:Search |
| Cancer Citations:Search |
| Toxicology Citations:Search |
| EPA Substance Registry Services (TSCA):556-67-2 |
| EPA ACToR:Toxicology Data |
| EPA Substance Registry Services (SRS):Registry |
| Laboratory Chemical Safety Summary :11169 |
| National Institute of Allergy and Infectious Diseases:Data |
| SCCNFP:opinion |
| WGK Germany:3 |
| 2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane |
| Chemidplus:0000556672 |
| RTECS:556-67-2 |
References:
| | 2,2,4,4,6,6,8,8-octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane |
| NIST Chemistry WebBook: | Search Inchi |
| Canada Domestic Sub. List: | 556-67-2 |
| Pubchem (cid): | 11169 |
| Pubchem (sid): | 134976880 |
Other Information:
Potential Blenders and core components note
Potential Uses:
Occurrence (nature, food, other): note
Synonyms:
| | cyclotetrasiloxane, 2,2,4,4,6,6,8,8-octamethyl- | | | cyclotetrasiloxane, octamethyl- | | 2,2,4,4,6,6,8,8- | octamethyl-1,3,5,7,2,4,6,8-tetraoxatetrasilocane | | 2,2,4,4,6,6,8,8- | octamethyl-1,3,5,7,2,4,6,8-tetroxatetrasilocane | | | union carbide 7207 | | | volasil 244 |
Articles:
| PubMed:Trophic transfer of methyl siloxanes in the marine food web from coastal area of northern china. |
| PubMed:Nanorheology by atomic force microscopy. |
| PubMed:Regeneration of siloxane-exhausted activated carbon by advanced oxidation processes. |
| PubMed:Occurrence of cyclic and linear siloxanes in indoor air from Albany, New York, USA, and its implications for inhalation exposure. |
| PubMed:Fate of anthropogenic cyclic volatile methylsiloxanes in a wastewater treatment plant. |
| PubMed:Aggregate dermal exposure to cyclic siloxanes in personal care products: implications for risk assessment. |
| PubMed:Measurement of cyclic volatile methylsiloxanes in the aquatic environment using low-density polyethylene passive sampling devices using an in-field calibration study--challenges and guidance. |
| PubMed:Comment on "Emergence and fate of cyclic volatile polydimethylsiloxanes (D4, D5) in municipal waste streams: release mechanisms, partitioning and persistence in air, water, soil and sediments". |
| PubMed:Organophosphate flame retardants and organosiloxanes in predatory freshwater fish from locations across Canada. |
| PubMed:Solvation force simulations in atomic force microscopy. |
| PubMed:Determination of soil-water sorption coefficients of volatile methylsiloxanes. |
| PubMed:Siloxanes removal from biogas by a lab-scale biotrickling filter inoculated with Pseudomonas aeruginosa S240. |
| PubMed:Biogas upgrading: optimal activated carbon properties for siloxane removal. |
| PubMed:Sensitive method for quantification of octamethylcyclotetrasiloxane (D4) and decamethylcyclopentasiloxane (D5) in end-exhaled air by thermal desorption gas chromatography mass spectrometry. |
| PubMed:Allometric relationships to liver tissue concentrations of cyclic volatile methyl siloxanes in Atlantic cod. |
| PubMed:Absorption of a linear (L2) and a cyclic (D4) siloxane using different oils: application to biogas treatment. |
| PubMed:Relevance of an organic solvent for absorption of siloxanes. |
| PubMed:Concentrations and trophic magnification of cyclic siloxanes in aquatic biota from the Western Basin of Lake Erie, Canada. |
| PubMed:Consistency in trophic magnification factors of cyclic methyl siloxanes in pelagic freshwater food webs leading to brown trout. |
| PubMed:Concentrations of cyclic volatile methylsiloxanes in European cosmetics and personal care products: prerequisite for human and environmental exposure assessment. |
| PubMed:Improving the efficiency of quantitative (1)H NMR: an innovative external standard-internal reference approach. |
| PubMed:Emergence and fate of cyclic volatile polydimethylsiloxanes (D4, D5) in municipal waste streams: release mechanisms, partitioning and persistence in air, water, soil and sediments. |
| PubMed:Atomic force microscopy of confined liquids using the thermal bending fluctuations of the cantilever. |
| PubMed:Composition and source identification of deposits forming in landfill gas (LFG) engines and effect of activated carbon treatment on deposit composition. |
| PubMed:Adsorption characteristics of siloxanes in landfill gas by the adsorption equilibrium test. |
| PubMed:Pharmacodynamic models: parameterizing the hill equation, Michaelis-Menten, the logistic curve, and relationships among these models. |
| PubMed:Cyclic siloxanes in air, including identification of high levels in Chicago and distinct diurnal variation. |
| PubMed:Calibration and application of a passive air sampler (XAD-PAS) for volatile methyl siloxanes. |
| PubMed:Selected ion flow tube studies of several siloxanes. |
| PubMed:Evaluating the fate and behaviour of cyclic volatile methyl siloxanes in two contrasting North American lakes using a multi-media model. |
| PubMed:Fathead minnow (Pimephales promelas) embryo to adult exposure to decamethylcyclopentasiloxane (D5). |
| PubMed:Mechanism of diffusion slowdown in confined liquids. |
| PubMed:Determination of cyclic volatile methylsiloxanes in water, sediment, soil, biota, and biosolid using large-volume injection-gas chromatography-mass spectrometry. |
| PubMed:Review of recent advances in research on the toxicity, detection, occurrence and fate of cyclic volatile methyl siloxanes in the environment. |
| PubMed:Plasma concentrations of cyclic volatile methylsiloxanes (cVMS) in pregnant and postmenopausal Norwegian women and self-reported use of personal care products (PCPs). |
| PubMed:Determination of the dietary biomagnification of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane with the rainbow trout (Oncorhynchus mykiss). |
| PubMed:Occurrence and seasonality of cyclic volatile methyl siloxanes in Arctic air. |
| PubMed:Occurrence and fate of volatile siloxanes in a municipal wastewater treatment plant of Beijing, China. |
| PubMed:Cyclic volatile methylsiloxanes in fish from the Baltic Sea. |
| PubMed:Junge relationships in measurement data for cyclic siloxanes in air. |
| PubMed:Concentrations of cyclic volatile methylsiloxanes in biosolid amended soil, influent, effluent, receiving water, and sediment of wastewater treatment plants in Canada. |
| PubMed:Comprehensive mass flow analysis of Swedish sludge contaminants. |
| PubMed:High refractive index polysiloxane as injectable, in situ curable accommodating intraocular lens. |
| PubMed:Determination of siloxanes in silicone products and potential migration to milk, formula and liquid simulants. |
| PubMed:Food web accumulation of cyclic siloxanes in Lake Mjøsa, Norway. |
| PubMed:Method for simultaneous determination of partition coefficients for cyclic volatile methylsiloxanes and dimethylsilanediol. |
| PubMed:A surprise from 1954: siloxane equilibration is a simple, robust, and obvious polymer self-healing mechanism. |
| PubMed:Quantitative force and dissipation measurements in liquids using piezo-excited atomic force microscopy: a unifying theory. |
| PubMed:Prioritizing organic chemicals for long-term air monitoring by using empirical monitoring data--application to data from the Swedish screening program. |
| PubMed:Cyclic volatile methylsiloxane bioaccumulation in flounder and ragworm in the Humber Estuary. |
| PubMed:Confinement-dependent damping in a layered liquid. |
| PubMed:Unraveling the properties of octamethylcyclotetrasiloxane under nanoscale confinement: atomistic view of the liquidlike state from molecular dynamics simulation. |
| PubMed:Survey of cyclic and linear siloxanes in sediment from the Songhua River and in sewage sludge from wastewater treatment plants, Northeastern China. |
| PubMed:Determination of cyclic volatile methylsiloxanes in biota with a purge and trap method. |
| PubMed:Nonlinear rheology of a nanoconfined simple fluid. |
| PubMed:Volatile siloxanes in the European arctic: assessment of sources and spatial distribution. |
| PubMed:High-resolution friction force microscopy under electrochemical control. |
| PubMed:Occurrence of cyclic and linear siloxanes in indoor dust from China, and implications for human exposures. |
| PubMed:Do epitaxy and temperature affect oscillatory solvation forces? |
| PubMed:Functionalised polysiloxanes as injectable, in situ curable accommodating intraocular lenses. |
| PubMed:Dissipation and oscillatory solvation forces in confined liquids studied by small-amplitude atomic force spectroscopy. |
| PubMed:Quantitative analysis of volatile methylsiloxanes in waste-to-energy landfill biogases using direct APCI-MS/MS. |
| PubMed:Siloxane treatment by adsorption into porous materials. |
| PubMed:Direct analysis of volatile methylsiloxanes in gaseous matrixes using atmospheric pressure chemical ionization-tandem mass spectrometry. |
| PubMed:Effect of ozone and relative humidity on the heterogeneous uptake of octamethylcyclotetrasiloxane and decamethylcyclopentasiloxane on model mineral dust aerosol components. |
| PubMed:Low molecular weight cyclic volatile methylsiloxanes in cosmetic products sold in Canada: implication for dermal exposure. |
| PubMed:Temperature dependence of solvation forces as measured in atomic force microscopy. |
| PubMed:Drainage of a nanoconfined simple fluid: rate effects on squeeze-out dynamics. |
| PubMed:Biological removal of siloxanes from landfill and digester gases: opportunities and challenges. |
| PubMed:A mechanistic study of cyclic siloxane pyrolyses at low pressures. |
| PubMed:Flow injection potentiometric determination of paraquat in formulations and biological samples. |
| PubMed:[Analysis of the volatile oils chemical constituents of roots of Actinidia deliciosa]. |
| PubMed:Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans. |
| PubMed:Are highly lipophilic volatile compounds expected to bioaccumulate with repeated exposures? |
| PubMed:Survey of organosilicone compounds, including cyclic and linear siloxanes, in personal-care and household products. |
| PubMed:Assessing kinetic determinants for metabolism and oral uptake of octamethylcyclotetrasiloxane (D4) from inhalation chamber studies. |
| PubMed:Effect of tip size on force measurement in atomic force microscopy. |
| PubMed:In vitro and in vivo percutaneous absorption of 14C-octamethylcyclotetrasiloxane (14C-D4) and 14C-decamethylcyclopentasiloxane (14C-D5). |
| PubMed:Physiologically based pharmacokinetic modeling of the disposition of octamethylcyclotetrasiloxane (D4) migration from implants in humans. |
| PubMed:Modeling of human dermal absorption of octamethylcyclotetrasiloxane (D(4)) and decamethylcyclopentasiloxane (D(5)). |
| PubMed:Effects of octamethylcyclotetrasiloxane (D4) on the luteinizing hormone (LH) surge and levels of various reproductive hormones in female Sprague-Dawley rats. |
| PubMed:Surface melting of octamethylcyclotetrasiloxane confined in controlled pore glasses: curvature effects observed by 1H NMR. |
| PubMed:An inhalation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in female rats using multiple and single day exposure regimens. |
| PubMed:A two-generation reproductive toxicity study of octamethylcyclotetrasiloxane (D4) in rats exposed by whole-body vapor inhalation. |
| PubMed:Recent progress in the determination of solid surface tensions from contact angles. |
| PubMed:In vitro and in vivo evaluation of the estrogenic, androgenic, and progestagenic potential of two cyclic siloxanes. |
| PubMed:NMR cryoporometry with octamethylcyclotetrasiloxane as a probe liquid. Accessing large pores. |
| PubMed:Effect of octamethylcyclotetrasiloxane on methylation of bismuth by Methanosarcina barkeri. |
| PubMed:Density functional theory calculation of (29)Si NMR chemical shifts of organosiloxanes. |
| PubMed:Diagnosing inborn errors of lipid metabolism with proton nuclear magnetic resonance spectroscopy. |
| PubMed:Oscillatory dissipation of a simple confined liquid. |
| PubMed:Discrete solvation layering in confined binary liquids. |
| PubMed:Interpretation of contact angle measurements on two different fluoropolymers for the determination of solid surface tension. |
| PubMed:How confined lubricants diffuse during shear. |
| PubMed:Contact angle measurements with liquids consisting of bulky molecules. |
| PubMed:Octamethylcyclotetrasiloxane exhibits estrogenic activity in mice via ERalpha. |
| PubMed:The measurement of conformational stability of proteins adsorbed on siloxanes. |
| PubMed:Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise. |
| PubMed:PBPK modeling advances understanding of D4 pharmacokinetics. |
| PubMed:Determination of siloxanes, silicon, and platinum in tissues of women with silicone gel-filled implants. |
| PubMed:Route-specific differences in distribution characteristics of octamethylcyclotetrasiloxane in rats: analysis using PBPK models. |
| PubMed:Further comments on the bioavailability of D4. |
| PubMed:Bioavailability of D4 after inhalation and implantation exposure to silicones. |
| PubMed:Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model. |
| PubMed:Dose-response modeling of cytochrome p450 induction in rats by octamethylcyclotetrasiloxane. |
| PubMed:The effect of cyclic swelling (octamethylcyclotetrasiloxane) on the physical properties of silicone breast implant shells. |
| PubMed:Effect of interfacial liquid structuring on the coherence length in nanolubrication. |
| PubMed:Inhalation toxicology of octamethylcyclotetrasiloxane (D4) following a 3-month nose-only exposure in Fischer 344 rats. |
| PubMed:Study of the advancing and receding contact angles: liquid sorption as a cause of contact angle hysteresis. |
| PubMed:Bioavailability of octamethylcyclotetrasiloxane (D(4)) after exposure to silicones by inhalation and implantation. |
| PubMed:The transport of octamethylcyclotetrasiloxane (D4) and polydimethylsiloxane (PDMS) in lightly cross-linked silicone rubber. |
| PubMed:Potential estrogenic and antiestrogenic activity of the cyclic siloxane octamethylcyclotetrasiloxane (D4) and the linear siloxane hexamethyldisiloxane (HMDS) in immature rats using the uterotrophic assay. |
| PubMed:Repeated inhalation exposure to octamethylcyclotetrasiloxane produces hepatomegaly, transient hepatic hyperplasia, and sustained hypertrophy in female Fischer 344 rats in a manner similar to phenobarbital. |
| PubMed:Physiological modeling reveals novel pharmacokinetic behavior for inhaled octamethylcyclotetrasiloxane in rats. |
| PubMed:Determination of low molecular weight silicones in plasma and blood of women after exposure to silicone breast implants by GC/MS. |
| PubMed:Permeation of substituted silanes and siloxanes through selected gloves and protective clothing. |
| PubMed:Genetic toxicity evaluation of octamethylcyclotetrasiloxane. |
| PubMed:Induction of rat hepatic drug metabolizing enzymes by dimethylcyclosiloxanes. |
| PubMed:Disposition of radioactivity in fischer 344 rats after single and multiple inhalation exposure to [(14)C]Octamethylcyclotetrasiloxane ([(14)C]D(4)). |
| PubMed:Toxicology and humoral immunity assessment of octamethylcyclotetrasiloxane (D4) following a 28-day whole body vapor inhalation exposure in Fischer 344 rats. |
| PubMed:Identification of metabolites of octamethylcyclotetrasiloxane (D(4)) in rat urine. |
| PubMed:Microbial degradation of octamethylcyclotetrasiloxane. |
| PubMed:Cyclosiloxanes produce fatal liver and lung damage in mice. |
| PubMed:Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects. |
| PubMed:Quantitative exposure of humans to an octamethylcyclotetrasiloxane (D4) vapor. |
| PubMed:Protein denaturation induced by cyclic silicone. |
| PubMed:Drug microencapsulation by PLA/PLGA coacervation in the light of thermodynamics. 2. Parameters determining microsphere formation. |
| PubMed:Evaluation of octamethylcyclotetrasiloxane (D4) as an inducer of rat hepatic microsomal cytochrome P450, UDP-glucuronosyltransferase, and epoxide hydrolase: a 28-day inhalation study. |
| PubMed:Low molecular weight silicones are widely distributed after a single subcutaneous injection in mice. |
| PubMed:Extraction of octamethylcyclotetrasiloxane and its metabolites from biological matrices. |
| PubMed:Force-distance curves by AFM. A powerful technique for studying surface interactions. |
| PubMed:Silicone gel and octamethylcyclotetrasiloxane (D4) enhances antibody production to bovine serum albumin in mice. |
| PubMed:Cytotoxicity and membrane damage in vitro by inclusion complexes between gamma-cyclodextrin and siloxanes. |
| PubMed:Silicone gel and octamethylcyclotetrasiloxane potentiate antibody production to bovine serum albumin in mice. |
| PubMed:The adjuvancy of silicones: dependency on compartmentalization. |
| PubMed:Induction of type II collagen arthritis in the DA rat using silicone gels and oils as adjuvant. |
| PubMed:The effect of molecular weight and gel preparation on humoral adjuvancy of silicone oils and silicone gels. |
| PubMed:Octamethylcyclotetrasiloxane in aquatic sediments: toxicity and risk assessment. |
| PubMed:Ocular toxicity of low-molecular-weight components of silicone and fluorosilicone oils. |
| PubMed:Use of plasma polymerization for preparing silicone-coated membranes for possible use in blood oxygenators. |
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